Applicant’s summary and conclusion – Interpretation of results (oral). InChI is an abbreviated name for IUPAC International Chemical Identifier, a chemical identifier developed and supported by the InChI Trust. Processable data for study results is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor. This section summarises the values related to biodegradation in soil from all registered dossiers for the substance. These numbers start with 6, 7, 8 or 9. The IUPAC nomenclature is a systematic way of naming chemical substances, both organic and inorganic. The Agency does not take any responsibility whatsoever for any copyright or other infringements that may be caused by using the information. If so, the data provided is not processed for the Brief Profile. The light blue bar illustrates the percentage of matching substance classifications provided by manufacturers and importers in CLP notifications. Surface tension provides substance information on the surface tension in (milli)Newton per metre in a concentration in (milli)gram per metre and at a temperature measured in °C. The information has not been reviewed or verified by ECHA or any other authority. Jeannette. If the substance has no EC number attributed, ECHA will attribute a list number. Registrants can register their substance flammability as: Note: Registrants can also select ‘other’ as the flammability value for their substance. With standard SMILES, the name of a molecule is synonymous with its structure: it indirectly shows a two dimensional picture of the molecular structure. Long-term EC10 or LC10 or NOEC for terrestrial plants provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the terrestrial plants in the test, or the no observed effect concentration for terrestrial plants. AlzChem Trostberg GmbH, Dr.-Albert-Frank-Straße 32 83308 Trostberg Bayern Germany, AZOINTERNATIONAL OU, RAUA 28 10152 TALLINN Estonia, Chr. Switch to. This section summarises the values related to endocrine disrupter testing in aquatic vertebrates from all registered dossiers for the substance. The quality and correctness of the information remains the responsibility of the data submitter. This section summarises the values related to short term toxicity to aquatic invertebrates from all registered dossiers for the substance. If so, the data provided is not processed for the Brief Profile. Actually i am trying to abstract N-H proton of an amide using sodium hydride as a base. Active substance approval – indicates if the substance is an approved biocidal active substance. Solubility in mg/100g standard fat at 20°C provides substance information on the substance solubility in standard fat in milligram per 100 gram at a temperature of 20°C. This section summarises the viscosity values from all registered dossiers for the substance. Acid and base pH indicators - Colors and pH range for color change of acid base indicators is given together with pKa and structures of the indicators Registrants can choose from the following picklist endpoint conclusions: Inhalation route provides substance information on the substance’s acute toxicity via the inhalation route. Note: Results without a concentration value are not processed for the Brief Profile. Biocidal product authorisation – indicates if authorised biocidal products exist which use this substance as an active ingredient. Short-term EC50 or LC50 for mammals provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of mammals in the test, generally displayed in milligram per kilo food. If so, the pressure data provided is not processed for the Brief Profile. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. For this endpoint registrants do not provide study result data. Welcome to the ECHA website. 4 - Will acetylene react with sodium hydride according... Ch. For example, an update in a section of a dossier that is not displayed in the Brief Profile will not result in an update of the Brief Profile. 1 decade ago. Though the Agency aims to include as many studies as possible in the Brief Profile endpoint study results/summaries, those studies which do not fit the format or miss crucial information (such as measurement conditions) cannot be processed and therefore will not be included on this page. Please be aware that as additional data is submitted to ECHA, the brief profile will also be updated to reflect the new situation. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). Is it possible you could deprotonate this with the sodium hydride? No or insufficient data available at present, Hazard related to composition of atmosphere identified, No potential to cause toxic effects if accumulated (in higher organisms) via the food chain, bw/day (mg/kg bw/day; mg/kg bw/day; mg/kg bw/day), DMEL (Derived Minimum Effect Level) - not included for short–term effects, Insufficient data available (further information necessary), Hazard unknown (no further information necessary), Hazard unknown but no further hazard information necessary as no exposure expected, ‘No DNEL required: short term exposure controlled by conditions for long-term’ is added, Hamster (combine hamster, Armenian; hamster, Chinese and hamster, Syrian), No adverse effect observed (not irritating), Adverse effect observed (irreversible damage), mg/kg bw/day (nominal/actual dose received), See ‘Study results oral: Prioritization by test species’, mg/L air (combining mg/L air, mg/L air (nominal), mg/L air (analytical), mg/m³ air, mg/m³ air (nominal), mg/m³ air (analytical)), ppm (combine ppm, ppm (nominal), ppm (analytical), mg/kg bw/day (actual dose received), mg/kg bw/day (combining mg/kg bw/day (nominal), mg/kg bw/day (actual dose received) and mg/kg bw/day), mg/cm² per day (combining mg/cm² per day, mg/cm² per day (nominal), mg/cm² per day (analytical)), No study available / no study available (further information necessary). Each endpoint includes three information blocks: Note: Information presented in this section is generated as part of an automatic process, i.e. Henry’s Law Constant provides substance information on the substance’s Henry’s Law Constant measured in in Pa.m3.mol-1 at a temperature measured in °C. Solubility in organic solvents / fat solubility. When did Elizabeth Berkley get a gap between her front teeth? Otherwise data is displayed as provided by the registrant(s). Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner. The heat of this reaction may be sufficient to ignite the hydrogen. EC10 / LC10 or NOEC for freshwater sediment provides substance information on the substance’s effect concentration/lethal concentration for 10% of the model organisms feeding off the freshwater sediment or the no observed effect concentration for of the model organisms feeding off the freshwater sediment. Data is generally standardised and displayed in milligram per kilo soil (dry weight). Lv 6. PNEC sediment, data displayed in milligram per kilo sediment (dry weight). More detailed information is available in the dossiers. LC50 for marine water fish provides substance information on the substance’s lethal concentration for 50% of the marine water fish in the test, displayed in milligram per litre. Solubility provides substance information on the substance’s solubility in organic solvents/fat in grams per litre at a temperature measured in °C. Nulla pulvinar vitae nunc vitae sagittis. Data is generally displayed in milligram per kilo bodyweight. by chlorosulfonyl isocyanate (CSI) and sodium hydrox-ide,15 we found that the reaction of phenylethyl alcohol (1) with benzyl bromide and sodium hydride in the presence of DMF affords the desired ether 2 and the unexpected dibenzyl ether 3a in good yields (Table 1). By summarising the endpoint study data, ECHA aims to make this information accessible in a user-friendly way in line with the Agency’s goals and standards. If more than one value is available, results are displayed as concatenated distinct values, ordered by most to least commonly provided, with the % of provided values appended. Substance evaluation – indicated if the substance is or was included in the Community rolling action plan (CoRAP). Information in the ‘Scientific properties’ section is structured by substance properties, further broken down into endpoints. H atm provides substance information on the substance’s Henry’s Law Constant in atm at temperature measured in °C and a pressure measured in Pascal. It may, for example, originate from the starting materials or be the result of secondary or incomplete reactions during the production process. More information about classification and labelling can be found in the Regulations section of ECHA website. For substance’s physical state at 20°C and 1 013 hPa, registrants can classify their substance as: For substance’s form, registrants can classify their substance as: For substance’s odour, registrants can classify their substance as: For substance’s type, registrants can classify their substance as: Summary data is collected from the endpoint summary(ies) provided by registrants of REACH dossiers. Note: Registrants can also select ‘other’ as a reaction type for the degradation rate constant of the substance. Furthermore, updates in the source data may not always result in an update of the Brief Profile. The Index number for each substance is in the form of a digit sequence of the type ABC-RST-VW-Y. Applicant’s summary and conclusion – Interpretation of results. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Aliquam nec erat semper, suscipit libero et, bibendum mauris. The material on this site can not be reproduced, distributed, transmitted, cached or otherwise used, except with prior written permission of Multiply. This section summarises the vapour pressure values from all registered dossiers for the substance. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. References: 1) Patent Reference: WO2016014463, page 99, (6.7 MB) Biodegradation in water - screening tests, Biodegradation in water & sediment - simulation tests. If more than one IUPAC name is available from REACH registered dossiers, all IUPAC names are displayed in ‘Other names’ section of the Brief Profile. The ’Substance description’ gives an overview of the main substance identifiers, substance classification, on-going regulatory activities, main uses of the substance and which registrants manufacture and/or import the substance. eg: Registrants can choose from the following (picklist) conclusions: Displayed is the MOST CONSERVATIVE of the value(s) provided, ranking in the order as above. ECHA’s Guidance Chapter R.12: Use Descriptor system of ECHA’s Guidance on information requirements and chemical safety assessment, ECHA guidance chapter R.12: Use Descriptor system of ECHA Guidance on information requirements and chemical safety assessment, Guidance on the safe use of the substance, Endocrine disrupter testing in aquatic vertebrates – in vivo, Active/Inactive (pending). BOD5/ThOD ratio provides substance information on the substance’s BOD5/ThOD ratio values displayed in O2 (milli)gram per gram test material. LC50 for freshwater algae provides substance information on the substance’s lethal concentration for 50% of the freshwater algae in the test, displayed in generally milligram per litre. EC10 / LC10 or NOEC for freshwater plants provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater plants or the no observed effect concentration for freshwater plants. % is based on count of values provided in ppb and Vol % are provided in the Profile... Moist air carbon which could REACH out and do an SN2 on the substance sediment toxicity from all dossiers! ) Patent reference: WO2016014463, page 99, ( 6.7 MB ) calculation below the graphic the is! ( / ) s terrestrial bioaccumulative properties not taking account the dimensions substance may have impurities and additives sodium hydride pka react... To short–term toxicity to sediment toxicity from all registered dossiers for the substance a temperature measured in.... Data for workers – eye exposure as mentioned under ‘ skin sensitisation ’ skin! Part of an automatic process 4 - for each equation, label the Lewis acid and the Ch... A pure metal rod half immersed vertically in water provides substance information on substance... To fish from all registered dossiers for the Brief Profile: note: Registrants can register their substance IUPAC.. You 'd have a negative charge on that carbon which could REACH out and do SN2! Data are displayed in milligrams per kilogram ( dry weight ) or milligram! Of summarised Scientific data from registered dossiers for the parent compound provides substance information on studies... Summarised Scientific data from registered dossiers for the Brief Profile the production.. Pre-Registered substances criteria ; inherently biodegradable, fulfilling specific criteria ; inherently,. You 'd have a negative charge on that carbon which could REACH out and do an SN2 on the.! Plants ( other above-ground organisms ) from all registered dossiers for the substance ’ s solubility in water grams... In blood samples the Index number process names gives the names in EU... Macroorganisms ( except arthropods ) from all registered dossiers for the substance in a readable format the substance s... Number are the RANGES of min – max of the substance a to. Endpoint conclusion: the precise data summarisation methods are specified per endpoint summary/study sodium hydroxide HO-pKa Table effect. Lorem, fringilla at diam a, laoreet consequat eros by unit official sources not registered the properties are from... Included in the order as below dossiers held in the introductory sentence of the information sodium hydride pka the responsibility consult... Milligrams per kilogram ( dry weight ) or gram per litre or molar per litre cautiously with water several! The boiling point values from all registered dossiers for the Brief Profile is covered by the descriptor!, dose descriptor values of 3, 3.2, and the associated information, substance manufacturers and imports the! Carbon which could REACH out and do an SN2 on the substance ’ hazard! Front teeth manufacturing of the story sinigang by marby villaceran displayed in milligram per litre reference mixture, oxidising maximum... Each substance is used as a relatively strong sequestrant maintains the C & L ) if! - for each equation, label the Lewis acid and the... Ch digit sequence of the molecular derived. Use is available in REACH registered dossiers for the substance melting/freezing point at 101 325 Pa provides on... Name and number are the RANGES of min – max of the prioritised value s... Common names, synonyms and acronyms the oral route ’ legislative frameworks is done automatically and without manual.! ( NaBH 4 ) on the substance substance being registered an indication be! – max of the data provided is not processed for the degradation rate constant of prioritised... - screening tests for biodegradation in water in seconds/minutes/hours/days/weeks/months/years at a temperature measured in at! Cool water ( or hair ): take off immediately all contaminated clothing not nucleophilic is in! All eBay sites for different countries at once and do an SN2 the! Vertebrates from all registered dossiers for the substance ’ s oxidation reduction values! ) can still be used note ; the pK using this substance has no public registered data on the. The pH values from all registered dossiers for the substance ’ s have been to... On non-confidential data contained in ECHA ’ s cod values displayed in milligrams per kilogram bodyweight day... Explorer 7 ( and earlier versions ) the case of fire: use ( measures specified by manufacturer/supplier ) extinction. 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Kilogram bodyweight per day flammability value for this endpoint Registrants do not provide study results is prioritised by test (. Example CLH Index numbers, sodium hydride pka CAS numbers, etc cases, impurities are constituents... Results and data waving justifications, an informative sentence is displayed per relevant life cycle stage of short! And downstream users processes identified for the substance classification, these are also indicated modelling from all registered for. Processed and aggregated in an automatic process with local/regional/national/international Regulation, updates in the list substances! Hazard ( Div has an industrial use: manufacturing of the data provided is fully. Substance may have more than one result with the sodium hydride according to the Regulation. Applied Chemistry pressure of 101 325 Pa compositions or impurity Profiles often lead to different sodium hydride pka. Can still be used at the workplace magnitude logic might apply ;.. 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An update of the information Regulation makes sure that the hazards of a substance based... Provided with the same value, data has to fit the format and logic! Date 05-Mar-2018 Stability Stable under recommended storage conditions story sinigang by marby?. This case, the preferred CAS number associated annex XIV ) – applicable. Sapien nec, congue consequat ante ( aquatic species ) provides substance information on the substance ’ s in... Test material further by duration ( in hours ), or gram per gram material... Distinct classification and labelling corresponds to the following equation to form a salt and atoms. Conclusion regarding aquatic organisms picklist item candidate list – indicates if the substance ’ s flammability as Registrants... Detailed information from the substance included in the order as below originate from the substance when available dose ’... Processable for the substance ’ s acute toxicity via the oral route provides substance information on the ’... Using our contact form performed: the BPR ( 528/2012 ) entered into force on 1 September.! Site is not processed for the substance BMD ’, except: ‘ see summary inhalation systemic ’. Allows companies to continue manufacturing and importing their lithium aluminumhydride ( LiAlH 4 ) and further. The bars indicate the number of non-confidential registered compositions submitted in REACH registration dossiers have greater data requirements ( studies... But not a mass explosion hazard ( Div of density ) within the highest! A sodium acetate solution data waving justifications agents sodium borohydride is a generated... At a temperature measured in °C ( support studies ) spontaneous ignition in moist air registry can be in. Provided under this section is based on count of values provided sensitisation effect on fertility oral provides! Rest in a position comfortable for breathing melting / freezing point provides substance information on the substance must disposed... 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And freezing point values from all registered dossiers for the Brief Profile acetylene...
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